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1
Epab is dispensable for mouse spermatogenesis and male fertility.Epab对小鼠精子发生和雄性生育能力并非必需。
Mol Reprod Dev. 2014 May;81(5):390. doi: 10.1002/mrd.22319. Epub 2014 Apr 4.
2
Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.胚胎多聚腺苷酸结合蛋白 (EPAB) 对于小鼠卵母细胞成熟和雌性生育力是必需的。
Biochem J. 2012 Aug 15;446(1):47-58. doi: 10.1042/BJ20120467.
3
The translational functions of embryonic poly(A)-binding protein during gametogenesis and early embryo development.胚胎多聚(A)结合蛋白在配子发生和早期胚胎发育中的翻译功能。
Mol Reprod Dev. 2019 Nov;86(11):1548-1560. doi: 10.1002/mrd.23253. Epub 2019 Aug 13.
4
Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.胚胎多聚(A)结合蛋白在小鼠卵泡发生的腔前卵泡阶段对于卵母细胞-体细胞通讯是必需的。
Biol Reprod. 2017 Feb 1;96(2):341-351. doi: 10.1095/biolreprod.116.141234.
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Knockout of MCT1 results in total absence of spermatozoa, sex hormones dysregulation, and morphological alterations in the testicular tissue.敲除 MCT1 会导致精子完全缺失、性激素失调以及睾丸组织形态改变。
Cell Tissue Res. 2019 Nov;378(2):333-339. doi: 10.1007/s00441-019-03028-4. Epub 2019 May 9.
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Adult rat seminiferous tubules secrete a fraction greater than 30 kDa to regulate spermatogenesis.成年大鼠的生精小管分泌一种分子量大于30 kDa的成分来调节精子发生。
Hum Reprod. 1995 Jun;10(6):1435-43. doi: 10.1093/humrep/10.6.1435.
7
Apoptosis, onset and maintenance of spermatogenesis: evidence for the involvement of Kit in Kit-haplodeficient mice.细胞凋亡、精子发生的起始与维持:Kit基因单倍体不足小鼠中Kit基因参与作用的证据
Biol Reprod. 2002 Jul;67(1):70-9. doi: 10.1095/biolreprod67.1.70.
8
Epab and Pabpc1 are differentially expressed during male germ cell development.Epab 和 Pabpc1 在雄性生殖细胞发育过程中呈现差异表达。
Reprod Sci. 2012 Sep;19(9):911-22. doi: 10.1177/1933719112446086. Epub 2012 Jul 18.
9
Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.超排卵改变小鼠卵母细胞和早期胚胎中胚胎多聚腺苷酸结合蛋白(Epab)和细胞质多聚腺苷酸结合蛋白1(Pabpc1)的基因表达。
Reprod Fertil Dev. 2016 Mar;28(3):375-83. doi: 10.1071/RD14106.
10
Assessment of spermatogenesis through staging of seminiferous tubules.通过生精小管分期评估精子发生。
Methods Mol Biol. 2013;927:299-307. doi: 10.1007/978-1-62703-038-0_27.

引用本文的文献

1
Mice lacking two testis-specific cytoplasmic poly(A)-binding proteins, PABPC2 and PABPC6, exhibit normal spermatogenesis and fertility.缺乏两种睾丸特异性细胞质聚腺苷酸结合蛋白PABPC2和PABPC6的小鼠表现出正常的精子发生和生育能力。
J Reprod Dev. 2025 Jun 6;71(3):154-160. doi: 10.1262/jrd.2025-012. Epub 2025 Apr 18.
2
Pathogenic missense variation in PABPC1L/EPAB causes female infertility due to oocyte maturation arrest at the germinal vesicle stage.PABPC1L/EPAB 中的致病变异导致卵母细胞在生发泡期停滞而引起女性不孕。
J Assist Reprod Genet. 2024 Feb;41(2):311-322. doi: 10.1007/s10815-023-03009-1. Epub 2024 Jan 5.
3
Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse.敲除睾丸特异性基因 C4orf46 不影响小鼠精子发生和生育能力。
Mamm Genome. 2021 Oct;32(5):364-370. doi: 10.1007/s00335-021-09879-z. Epub 2021 Jun 2.
4
Spermatogenesis is normal in knockout mice.在基因敲除小鼠中,精子发生是正常的。
PeerJ. 2020 Jul 29;8:e9629. doi: 10.7717/peerj.9629. eCollection 2020.
5
Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).卵母细胞和早期胚胎中母体来源 mRNA 的翻译激活以及胚胎多聚(A)结合蛋白(EPAB)的作用。
Biol Reprod. 2019 May 1;100(5):1147-1157. doi: 10.1093/biolre/ioz034.
6
Potential roles of the poly(A)-binding proteins in translational regulation during spermatogenesis.多聚腺苷酸结合蛋白在精子发生过程中的翻译调控中的潜在作用。
J Reprod Dev. 2018 Aug 20;64(4):289-296. doi: 10.1262/jrd.2018-026. Epub 2018 May 18.
7
Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.小鼠精子发生过程中睾丸特异性聚腺苷酸结合蛋白PABPC2缺失的功能补偿
J Reprod Dev. 2016 Jun 17;62(3):305-10. doi: 10.1262/jrd.2016-023. Epub 2016 Mar 13.
8
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.聚腺苷酸结合蛋白基因EPAB、PABPC1和PABPC3在非梗阻性无精子症的不育男性中差异表达。
J Assist Reprod Genet. 2016 Mar;33(3):335-348. doi: 10.1007/s10815-016-0654-z. Epub 2016 Feb 3.
9
Poly(A)-binding proteins are required for diverse biological processes in metazoans.聚腺苷酸结合蛋白是后生动物多种生物学过程所必需的。
Biochem Soc Trans. 2014 Aug;42(4):1229-37. doi: 10.1042/BST20140111.

本文引用的文献

1
Epab and Pabpc1 are differentially expressed during male germ cell development.Epab 和 Pabpc1 在雄性生殖细胞发育过程中呈现差异表达。
Reprod Sci. 2012 Sep;19(9):911-22. doi: 10.1177/1933719112446086. Epub 2012 Jul 18.
2
Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.胚胎多聚腺苷酸结合蛋白 (EPAB) 对于小鼠卵母细胞成熟和雌性生育力是必需的。
Biochem J. 2012 Aug 15;446(1):47-58. doi: 10.1042/BJ20120467.
3
Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility.DNA/RNA结合蛋白MSY2的缺失导致雄性和雌性不育。
Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5755-60. doi: 10.1073/pnas.0408718102. Epub 2005 Apr 11.

Epab is dispensable for mouse spermatogenesis and male fertility.

作者信息

Ozturk Saffet, Guzeloglu-Kayisli Ozlem, Lowther Katie M, Lalioti Maria D, Sakkas Denny, Seli Emre

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut.

Department of Histology and Embryology, Akdeniz University, School of Medicine, Campus, Antalya, Turkey.

出版信息

Mol Reprod Dev. 2014 May;81(5):390. doi: 10.1002/mrd.22319. Epub 2014 Apr 4.

DOI:10.1002/mrd.22319
PMID:24599567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4079073/
Abstract
摘要