出血性大疱性淀粉样变：对两名患者的组织学、免疫细胞化学及超微结构研究
Hemorrhagic bullous amyloidosis. A histologic, immunocytochemical, and ultrastructural study of two patients.
作者信息
Bieber T, Ruzicka T, Linke R P, von Kries R, Goerz G, Braun-Falco O
机构信息
Department of Dermatology, Ludwig-Maximilians University, Munich, West Germany.
出版信息
Arch Dermatol. 1988 Nov;124(11):1683-6. doi: 10.1001/archderm.124.11.1683.
In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A lambda serum in both patients.
在皮肤大疱性出血性淀粉样变患者中，皮肤病变是浆细胞异常增生的首发表现。两例患者均具有相似的临床、组织学和超微结构表现，即在淀粉样物质沉积内出现真皮内水疱。用一组针对淀粉样原纤维蛋白的抗体进行免疫组织学研究显示，两名患者的淀粉样沉积物均与抗Aλ血清发生反应。
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