Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center New York, NY, USA.
Department of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center New York, NY, USA ; Macedonia Academy of Science and Arts Skopje, Macedonia.
Front Physiol. 2014 Feb 19;5:56. doi: 10.3389/fphys.2014.00056. eCollection 2014.
Mechanisms underlying brain arterial remodeling are uncertain. We tested the hypothesis that arterial size and location are important determinants of arterial characteristics. We collected large and penetrating brain arteries from cadavers with and without HIV. Morphometric characterization was obtained from digital images using color-based thresholding. The association of arterial size and location with lumen diameter, media and adventitia area, media proportion, a wall thickness, wall-to-lumen ratio and stenosis was obtained with multilevel mixed models and a P value ≤ 0.05 was considered significant. We included 336 brains, in which 2279 large arteries and 1488 penetrating arteries were identified. We found that arterial size was significantly associated with all arterial characteristics studied of large and penetrating arteries with exception of arterial stenosis in large arteries. After adjusting for size, an independent association was found between lumen diameters, media and adventitia thickness with artery locations. Arterial stenosis was also associated with artery location in both large and penetrating arteries. In summary, significant effects of size and/or location were found in arterial characteristics typically used to define arterial remodeling. Brain arterial remodeling characteristics differ across arterial sizes and location, and these differences should be controlled for in future studies of brain arterial remodeling.
脑动脉重塑的机制尚不清楚。我们检验了以下假设：动脉的大小和位置是动脉特征的重要决定因素。我们收集了来自有和没有 HIV 的尸体的大脑大而穿透性动脉。使用基于颜色的阈值的数字图像进行形态计量特征描述。使用多级混合模型获得动脉大小和位置与管腔直径、中膜和外膜面积、中膜比例、壁厚度、壁厚与管腔比以及狭窄的相关性，P 值≤0.05 被认为具有统计学意义。我们纳入了 336 例大脑，其中鉴定出 2279 条大血管和 1488 条穿透性血管。我们发现，除了大血管中的动脉狭窄外，动脉大小与大、穿透性动脉的所有研究动脉特征均显著相关。在调整大小后，发现管腔直径、中膜和外膜厚度与动脉位置之间存在独立的关联。动脉狭窄也与大、穿透性动脉中的动脉位置相关。总之，在通常用于定义动脉重塑的动脉特征中发现了大小和/或位置的显著影响。脑动脉重塑特征在动脉大小和位置上存在差异，在未来的脑动脉重塑研究中应控制这些差异。
