Neto L C de Albuquerque, Soares J M, Giusa-Chiferi M G, Gonçalves W J, Baracat E C
Department of Gynecology, Federal University of São Paulo Escola Paulista de Medicina, São Paulo, Brazil.
Department of Obstetrics and Gynecology, Facultade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Eur J Gynaecol Oncol. 2013;34(6):509-12.
To evaluate p53 protein expression in the endometrial polyp and compare with adenocarcinoma and atrophic endometrium of postmenopausal women.
Ninety-eight postmenopausal women were included in this study and divided into three groups related to histopathologic diagnosis: Group A--endometrial adenocarcinoma (n = 40), Group B--endometrial polyp (n = 38), and Group C--endometrial atrophy (n = 20). The length of this study was from 1990 to 2004. The endometrial samples were collected from hysteroscopic biopsy or surgery then processed for histopathologic routine. One thousand cells of each histological section were evaluated for immunohistochemical analysis using p53 antibodies. The ANOVA test was performed for the statistical analysis.
The expression of p53 in adenocarcinoma samples was the highest. The expression of polyp was positive when associated to hyperplasia without atypia. All samples of atrophic endometrial were negative.
The present data suggested that presence of hyperplasia in the endometrial polyp is factor to increase the expression of p53.
评估p53蛋白在子宫内膜息肉中的表达，并与绝经后女性的腺癌及萎缩性子宫内膜进行比较。
本研究纳入98例绝经后女性，根据组织病理学诊断分为三组：A组——子宫内膜腺癌（n = 40），B组——子宫内膜息肉（n = 38），C组——子宫内膜萎缩（n = 20）。研究时间为1990年至2004年。通过宫腔镜活检或手术采集子宫内膜样本，然后进行组织病理学常规处理。使用p53抗体对每个组织学切片的1000个细胞进行免疫组织化学分析评估。采用方差分析进行统计学分析。
腺癌样本中p53的表达最高。息肉与无异型增生的增生相关时表达为阳性。所有萎缩性子宫内膜样本均为阴性。
目前的数据表明，子宫内膜息肉中存在增生是增加p53表达的因素。
