姑息治疗人群中不安腿综合征的症状：发生率及影响

Symptoms of restless legs syndrome in a palliative care population: frequency and impact.

作者信息

Walia Harneet K, Shalhoub George, Ramsammy Verai, Harrington Michael, Thornton J Daryl, Auckley Dennis

机构信息

Center for Sleep Disorders, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Division of Internal Medicine, Womack Army Medical Center, Fort Bragg, North Carolina, USA.

出版信息

J Palliat Care. 2013 Winter;29(4):210-6.

PMID:24601071

Abstract

OBJECTIVES

We hypothesized that restless legs syndrome (RLS) would be common and associated with impaired quality of life (QOL) among palliative care outpatients.

METHODS

76 palliative care clinic patients completed the National Institutes of Health restless legs syndrome (NIH-RLS) screening questionnaire. Questionnaire data was also gathered on RLS severity and RLS-related QOL, and the Short Form Health Survey (SF-12) was used to measure QOL. Analysis was performed for associations between RLS categorization and QOL measures.

RESULTS

31 patients (40.8 percent) met criteria for RLS. RLS-positive patients had moderate-to-severe RLS symptoms and impaired RLS-specific QOL. RLS-positive patients scored lower on the mental component of the SF-12 (39 +/- 11 versus 45 +/- 12, p=0.03), though not on the physical component. In a multivariate regression analysis, higher levels of RLS severity had 2-point lower SF-12 mental component scores compared to lower levels of RLS severity (p=0.04), with no difference in physical component scores (p=0.47).

CONCLUSION

RLS appears common in palliative care outpatients and is associated with impairments in QOL.

摘要

目的

我们假设不安腿综合征（RLS）在姑息治疗门诊患者中很常见，且与生活质量（QOL）受损有关。

方法

76名姑息治疗门诊患者完成了美国国立卫生研究院不安腿综合征（NIH-RLS）筛查问卷。还收集了关于RLS严重程度和与RLS相关的生活质量的问卷数据，并使用简短健康调查问卷（SF-12）来测量生活质量。对RLS分类与生活质量测量之间的关联进行了分析。

结果

31名患者（40.8%）符合RLS标准。RLS阳性患者有中度至重度RLS症状，且RLS特异性生活质量受损。RLS阳性患者在SF-12的心理成分得分较低（39±11对45±12，p=0.03），但在身体成分得分上没有差异。在多变量回归分析中，与较低RLS严重程度相比，较高RLS严重程度的SF-12心理成分得分低2分（p=0.04），身体成分得分无差异（p=0.47）。