Lagrange J L, Thyss A, Caldani C, Héry M, Schneider M, Bensadoun J R
Radiotherapy Department, Centre Antoine-Lacassagne, Nice, France.
Bull Cancer. 1988;75(8):801-6.
The authors report on 5 Hodgkin's disease (HD) patients with a mediastinothoracic ratio greater than or equal to 0.35 treated by ABVD chemotherapy (adriamycin, bleomycin, vindesine, DTIC) and irradiation. All 5 patients developed complications and there was 1 death. Administration of adriamycin and bleomycin in combination with irradiation may have been responsible for this poor treatment tolerance. Use of such protocols, and especially use of ABVD after mediastinal irradiation, should probably be avoided in the management of patients with massive mediastinal involvement.
作者报告了5例霍奇金病（HD）患者，其纵隔胸廓比大于或等于0.35，接受了ABVD化疗（阿霉素、博来霉素、长春地辛、达卡巴嗪）和放疗。所有5例患者均出现并发症，1例死亡。阿霉素和博来霉素联合放疗可能是导致这种治疗耐受性差的原因。在治疗广泛纵隔受累的患者时，应避免使用此类方案，尤其是在纵隔放疗后使用ABVD。
