Genazzani Alessandro D, Santagni Susanna, Rattighieri Erika, Chierchia Elisa, Despini Giulia, Marini Giulia, Prati Alessia, Simoncini Tommaso
Department of Obstetrics and Gynecology, Gynecological Endocrinology Centre, University of Modena and Reggio Emilia , Modena , Italy.
Gynecol Endocrinol. 2014 Jun;30(6):438-43. doi: 10.3109/09513590.2014.897321. Epub 2014 Mar 7.
Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26). After the treatment, interval several endocrine parameters improved (luteinizing hormone [LH], LH/follicle stimulating hormone [FSH], androstenedione and insulin), insulin response to oral glucose tolerance test reported the significant improvement of insulin sensitivity as well as the gonadotropin-releasing hormone (GnRH)-induced (10 µg, in bolus) LH response. BMI decreased, though no lifestyle modification was requested. When data were analyzed according to the presence or absence of first-grade diabetic relatives, PCOS patients with diabetic relatives showed greater improvement after DCI administration. In conclusion DCI administration is effective in restoring better insulin sensitivity and an improved hormonal pattern in obese hyperinsulinemic PCOS patients, in particular, in hyperinsulinemic PCOS patients who have diabetic relatives.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，通过排卵稀少、雄激素过多和卵巢多囊形态影响生育能力。由于已证明PCOS患者中胰岛素抵抗的发生率很高，我们的研究旨在评估给予D-手性肌醇（DCI）（每日500毫克，口服，共12周）对一组超重/肥胖PCOS患者（体重指数；BMI＞26）的激素参数和胰岛素敏感性的综合治疗效果。治疗后，多个内分泌参数得到改善（促黄体生成素[LH]、LH/促卵泡生成素[FSH]、雄烯二酮和胰岛素），口服葡萄糖耐量试验的胰岛素反应显示胰岛素敏感性显著改善，以及促性腺激素释放激素（GnRH）诱导（10微克，静脉推注）的LH反应。尽管未要求改变生活方式，但BMI有所下降。当根据是否有一级糖尿病亲属分析数据时，有糖尿病亲属的PCOS患者在给予DCI后改善更大。总之，给予DCI对恢复肥胖高胰岛素血症PCOS患者，特别是有糖尿病亲属的高胰岛素血症PCOS患者更好的胰岛素敏感性和改善激素模式有效。
