家兔输卵管肌肉组织的体内胆碱能刺激
In vivo cholinergic stimulation of the rabbit oviductal musculature.
作者信息
Howe G R, Jeveli E
出版信息
Int J Fertil. 1977;22(4):247-50.
The in vivo activity of the rabbit oviductal musculature was evaluated in terms of constant rate perfusion resistance. Efforts to compare adrenergic and cholinergic stimulation showed that both pilocarpine and bethanechol chloride increased muscular activity 17-24% of that induced by epinephrine. The cholinergic stimulatory effect was reduced by adrenergic alpha blockade and completely abolished by cholinergic blockade or norepinephrine depletion. The data suggest that cholinergic stimulation of the tubal musculature is mediated, in part, via postganglionic adrenergic nerve fibers. It would appear that the oviductal musculature is not a primary target tissue for systemically administered autonomic agonists or antagonists.
通过恒定速率灌注阻力评估兔输卵管肌肉组织的体内活性。比较肾上腺素能和胆碱能刺激的研究表明，毛果芸香碱和氯化贝胆碱均可使肌肉活性增加，幅度为肾上腺素诱导活性的17%-24%。肾上腺素能α受体阻断可降低胆碱能刺激作用，胆碱能阻断或去甲肾上腺素耗竭则可使其完全消除。数据表明，输卵管肌肉组织的胆碱能刺激部分是通过节后肾上腺素能神经纤维介导的。看来输卵管肌肉组织并非全身给药的自主激动剂或拮抗剂的主要靶组织。
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