Matula C, Nahler G, Kreuzig F
Department of Medicine, Biochemie Ges. m.b.H., Vienna, Austria.
Int J Clin Pharmacol Res. 1988;8(4):259-61.
Three pharmaceutical preparations for the disinfection of the oropharynx were tested with regard to the gramicidin concentration obtained in the saliva after their appropriate application. Peak values followed a dose-concentration relationship and were highest after sucking a lozenge containing 10 mg tyrothricin (mean 109.3 mg/L) followed by that of a gargle/mouth-wash containing 667 mg tyrothricin/L (mean 21.1 mg/L) and of a lozenge containing 4 mg tyrothricin (mean 14.4 mg/L).
对三种用于口咽消毒的药物制剂进行了测试，观察其在适当使用后唾液中短杆菌肽的浓度。峰值呈现剂量-浓度关系，在含10mg短杆菌肽的含片（平均109.3mg/L）、含667mg/L短杆菌肽的漱口水（平均21.1mg/L）以及含4mg短杆菌肽的含片（平均14.4mg/L）使用后，峰值最高。
