Shaoul R, Higaze H, Lavy A
Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
Aliment Pharmacol Ther. 2006 Aug 15;24(4):687-94. doi: 10.1111/j.1365-2036.2006.03023.x.
Among the randomized controlled trials evaluating the effect of pharyngeal anaesthesia only some suggest benefit. Spray is irritating for some people and leaves bitter taste in the throat. We hypothesized that delivering the local anaesthetic as a sucking lozenge would benefit the patients in terms of decreasing anxiety and will improve procedure performance and patient tolerance.
To determine whether benzocaine/tyrothricin sucking lozenges with conscious sedation is superior to conscious sedation alone, with respect to procedure performance and tolerance in patients undergoing upper endoscopy.
One hundred and seventy-four adult patients undergoing upper endoscopy with conscious sedation completed the study. They were randomized to receive sucking lozenge containing benzocaine or placebo before the procedure. Patients were asked to rate prestudy anxiety, tolerance for topical pharyngeal anaesthesia, comfort during endoscopy, degree of difficulty of intubation, postprocedure throat discomfort and willingness to undergo subsequent examinations using a 10-cm visual analogue scale. Endoscopists were asked to estimate the ease of oesophageal intubation and procedure performance.
No significant statistical differences regarding all the points studied were found between the groups.
Topical pharyngeal anaesthesia with benzocaine/tyrothricin lozenges with conscious sedation has no advantages over conscious sedation alone in patients undergoing upper endoscopy.
在评估咽部麻醉效果的随机对照试验中，只有部分试验显示出益处。喷雾对一些人有刺激性，且会在喉咙中留下苦味。我们推测，将局部麻醉剂制成含片让患者含服，在减轻焦虑方面对患者有益，还能改善操作过程及患者耐受性。
确定在接受上消化道内镜检查的患者中，含苯佐卡因/短杆菌肽的含片联合清醒镇静在操作过程及耐受性方面是否优于单纯清醒镇静。
174例接受清醒镇静下上消化道内镜检查的成年患者完成了该研究。他们在操作前被随机分组，分别接受含苯佐卡因的含片或安慰剂。患者被要求使用10厘米视觉模拟量表对检查前的焦虑程度、对咽部局部麻醉的耐受性、内镜检查期间的舒适度、插管难度、检查后的咽喉不适程度以及接受后续检查的意愿进行评分。内镜医师被要求评估食管插管的难易程度及操作过程。
两组在所有研究点上均未发现显著统计学差异。
对于接受上消化道内镜检查的患者，含苯佐卡因/短杆菌肽含片的咽部局部麻醉联合清醒镇静并不比单纯清醒镇静更具优势。
