JAMA Ophthalmol. 2014 May;132(5):637-9. doi: 10.1001/jamaophthalmol.2014.498.
Dermal injection of cosmetic fillers can lead to irreversible blindness when injected in the forehead, and this possible adverse effect is not typically mentioned to patients.
Vision loss from central retinal artery occlusion occurring, after cosmetic facial enhancement, was irreversible in 3 patients. However, 1 patient had a small amount of recovery with aggressive therapy.
Cosmetic facial fillers are not approved for use in the forehead, but off-label use for enhancement in this region is common. To our knowledge, there have been no prior reports of blindness caused by filler injected into the forehead. We present findings of central retinal artery occlusion due to fillers in 3 patients shortly after their cosmetic procedures. The filler presumably enters the central retinal artery via the rich external-internal carotid anastomoses and becomes embedded in the retinal tissues, potentially leading to irreversible and severe vision loss. Physicians performing cosmetic enhancement procedures involving facial fillers need to be aware of this potential complication and should include significant vision loss as a possible rare complication.
当填充物被注射到额头时，会导致不可逆转的失明，这是一种潜在的不良反应，但通常不会向患者提及。
3 名接受过美容面部增强治疗的患者出现了视网膜中央动脉阻塞导致的视力丧失，且无法恢复。然而，1 名患者通过积极治疗，视力有了一定程度的恢复。
美容面部填充物未被批准用于额头，但在该区域的非适应证使用很常见。据我们所知，尚无填充物注射到额头导致失明的先前报告。我们报告了 3 名患者在接受美容手术后不久发生的由于填充物导致的视网膜中央动脉阻塞的结果。填充物可能通过丰富的颈内外动脉吻合支进入视网膜中央动脉，并嵌入视网膜组织，可能导致不可逆转和严重的视力丧失。进行涉及面部填充物的美容增强手术的医生需要意识到这种潜在的并发症，并应将视力严重丧失作为一种罕见的可能并发症。
