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对精神药物药物遗传学检测的积极认知。

Positive perception of pharmacogenetic testing for psychotropic medications.

作者信息

Lanktree Matthew B, Zai Gwyneth, Vanderbeek Laura E, Giuffra Daniel E, Smithson David S, Kipp Lucas B, Dalseg Timothy R, Speechley Mark, Kennedy James L

机构信息

Department of Medicine, School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada; Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

出版信息

Hum Psychopharmacol. 2014 May;29(3):287-91. doi: 10.1002/hup.2383. Epub 2014 Mar 7.

Abstract

INTRODUCTION

Pharmacogenetics attempts to identify inter-individual genetic differences that are predictive of variable drug response and propensity to side effects, with the prospect of assisting physicians to select the most appropriate drug and dosage for treatment. However, many concerns regarding genetic tests exist. We sought to test the opinions of undergraduate science and medical students in southern Ontario universities toward pharmacogenetic testing.

METHODS AND RESULTS

Questionnaires were completed by 910 undergraduate medicine and science students from 2005 to 2007. Despite students' concerns that the results of genetic tests may be used for other purposes without consent (71%) or lead to discrimination (78%), an overwhelming number of students were in favor of pharmacogenetic testing (90%).

DISCUSSION

To our knowledge, this study is the first to survey a large sample for their attitude toward pharmacogenetic testing for psychotropic medications. Our results indicate that, although concerns remain and scientific advancements are required, respondents were in support of pharmacogenetic testing for medications used to treat schizophrenia. © 2014 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd.

摘要

引言

药物遗传学试图识别个体间的基因差异,这些差异可预测药物反应的变异性和副作用倾向,有望帮助医生选择最合适的药物和治疗剂量。然而,人们对基因检测存在诸多担忧。我们试图了解安大略省南部大学的本科理科和医科学生对药物遗传学检测的看法。

方法与结果

2005年至2007年,910名本科医科和理科学生完成了问卷调查。尽管学生们担心基因检测结果可能未经同意被用于其他目的(71%)或导致歧视(78%),但绝大多数学生支持药物遗传学检测(90%)。

讨论

据我们所知,本研究首次对大量样本进行调查,了解他们对精神药物药物遗传学检测的态度。我们的结果表明,尽管担忧仍然存在且需要科学进步,但受访者支持对用于治疗精神分裂症的药物进行药物遗传学检测。© 2014作者。《人类精神药理学:临床与实验》由约翰·威利父子有限公司出版。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445e/4237188/0e0972a723c2/hup0029-0287-f1.jpg

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