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本文引用的文献

1
Pharmacogenomically actionable medications in a safety net health care system.安全网医疗保健系统中具有药物基因组学可操作性的药物。
SAGE Open Med. 2016 Jan 7;4:2050312115624333. doi: 10.1177/2050312115624333. eCollection 2016.
2
"Getting off the Bus Closer to Your Destination": Patients' Views about Pharmacogenetic Testing.“在更接近目的地处下车”:患者对药物遗传学检测的看法
Perm J. 2015 Summer;19(3):21-7. doi: 10.7812/TPP/15-046. Epub 2015 Jun 1.
3
Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients.基于基因指导的他汀类药物治疗对他汀类药物认知、依从性和降胆固醇作用的影响:初级保健患者中一项试点实施研究。
J Pers Med. 2014 Mar 27;4(2):147-62. doi: 10.3390/jpm4020147.
4
Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting.在初级医疗环境中由药剂师辅助进行药物遗传学检测的初步研究。
Pharmacogenomics. 2014 Sep;15(13):1677-86. doi: 10.2217/pgs.14.109.
5
Public perceptions of pharmacogenetics.公众对药物遗传学的看法。
Pediatrics. 2014 May;133(5):e1258-67. doi: 10.1542/peds.2013-1416.
6
Positive perception of pharmacogenetic testing for psychotropic medications.对精神药物药物遗传学检测的积极认知。
Hum Psychopharmacol. 2014 May;29(3):287-91. doi: 10.1002/hup.2383. Epub 2014 Mar 7.
7
Direct-to-consumer pharmacogenomic testing is associated with increased physician utilisation.直接面向消费者的药物基因组检测与医生利用率的提高有关。
J Med Genet. 2014 Feb;51(2):83-9. doi: 10.1136/jmedgenet-2013-101909. Epub 2013 Dec 16.
8
Stakeholder views on pharmacogenomic testing.利益相关者对药物基因组检测的看法。
Pharmacotherapy. 2014 Feb;34(2):151-65. doi: 10.1002/phar.1364. Epub 2013 Oct 24.
9
Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial.为患者提供药物遗传学检测结果会影响其他汀类药物治疗的依从性:附加 KIF6 风险可更好地增加他汀类药物治疗依从性(AKROBATS)试验的结果。
Pharmacogenomics J. 2014 Jun;14(3):272-80. doi: 10.1038/tpj.2013.27. Epub 2013 Aug 27.
10
Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis.住院患者药物不良反应的频率:系统评价和荟萃分析。
Pharmacoepidemiol Drug Saf. 2012 Nov;21(11):1139-54. doi: 10.1002/pds.3309. Epub 2012 Jul 4.

患者在基层医疗环境中进行药物遗传学检测的经历。

Patient experiences with pharmacogenetic testing in a primary care setting.

作者信息

Haga Susanne B, Mills Rachel, Moaddeb Jivan, Allen Lapointe Nancy, Cho Alex, Ginsburg Geoffrey S

机构信息

Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, 304 Research Drive, Durham, NC 27708, USA.

Duke Clinical Research Institute, Duke University, Durham, NC 22708, USA.

出版信息

Pharmacogenomics. 2016 Oct;17(15):1629-1636. doi: 10.2217/pgs-2016-0077. Epub 2016 Sep 20.

DOI:10.2217/pgs-2016-0077
PMID:27648637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5558503/
Abstract

AIM

To investigate patient experiences with pharmacogenetic (PGx) testing.

METHODS

Patients were offered PGx testing through a study on pharmacist-assisted delivery of PGx testing and invited to complete pre- and post-testing surveys about their experience.

RESULTS

Of 63 patients tested, 17 completed the baseline survey (27%). Interest in testing was mostly impacted by desire to inform selection of best treatment (n = 13). Seven of 12 patients that completed the follow-up survey indicated that their provider discussed the test result with them. Five patients understood their test result very or somewhat well. All would be likely to have PGx testing again.

CONCLUSION

Patients perceived PGx testing to be useful, though more effort may be needed to improve patient-provider communication of test results.

摘要

目的

调查患者进行药物遗传学(PGx)检测的体验。

方法

通过一项关于药剂师辅助进行PGx检测的研究,为患者提供PGx检测,并邀请他们完成检测前和检测后的体验调查。

结果

在接受检测的63名患者中,17名完成了基线调查(27%)。对检测的兴趣主要受到希望为选择最佳治疗提供依据的影响(n = 13)。在完成随访调查的12名患者中,7名表示其医疗服务提供者与他们讨论了检测结果。5名患者对其检测结果理解得非常好或较好。所有人都可能会再次进行PGx检测。

结论

患者认为PGx检测有用,不过可能需要付出更多努力来改善医疗服务提供者与患者之间关于检测结果的沟通。