多药耐药铜绿假单胞菌临床分离株VRFPA06和VRFPA08与VRFPA07的比较基因组分析
Comparative Genomic Analysis of Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates VRFPA06 and VRFPA08 with VRFPA07.
作者信息
Murugan Nandagopal, Malathi Jambulingam, Umashankar Vetrivel, Madhavan Hajib Narahari Rao
机构信息
Dept. of Microbiology, L & T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
出版信息
Genome Announc. 2014 Mar 6;2(2):e00140-14. doi: 10.1128/genomeA.00140-14.
Abstract
Pseudomonas aeruginosa isolates harboring acquired drug-resistant genes lead to increased mortality. Here, we have sequenced and annotated the genomes of two multidrug-resistant (MDR) P. aeruginosa isolates and a susceptible P. aeruginosa clinical isolate evidencing divergent antibiotic susceptibilities. Genomic analysis showed insight on the different genomic strategies adapted by P. aeruginosa to combat antimicrobial effects.
摘要
携带获得性耐药基因的铜绿假单胞菌分离株会导致死亡率上升。在此，我们对两株多重耐药（MDR）铜绿假单胞菌分离株和一株药敏性不同的铜绿假单胞菌临床敏感株进行了基因组测序和注释。基因组分析揭示了铜绿假单胞菌为对抗抗菌作用而采用的不同基因组策略。
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