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Unraveling genomic and phenotypic nature of multidrug-resistant (MDR) Pseudomonas aeruginosa VRFPA04 isolated from keratitis patient.解析从角膜炎患者分离出的多重耐药铜绿假单胞菌VRFPA04的基因组和表型特征。
Microbiol Res. 2016 Dec;193:140-149. doi: 10.1016/j.micres.2016.10.002. Epub 2016 Oct 19.
2
Resistome and pathogenomics of multidrug resistant (MDR) Pseudomonas aeruginosa VRFPA03, VRFPA05 recovered from alkaline chemical keratitis and post-operative endophthalmitis patient.从碱性化学性角膜炎和术后眼内炎患者中分离出的多重耐药铜绿假单胞菌VRFPA03、VRFPA05的耐药基因组和病原体组学
Gene. 2016 Mar 1;578(1):105-11. doi: 10.1016/j.gene.2015.12.022. Epub 2015 Dec 10.
3
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.从血流感染中分离出的产blaVeb-1、blaoxa-10多药耐药（MDR）铜绿假单胞菌菌株VRFPA09的基因组序列草图
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4
Comparative Genomic Analysis of Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates VRFPA06 and VRFPA08 with VRFPA07.多药耐药铜绿假单胞菌临床分离株VRFPA06和VRFPA08与VRFPA07的比较基因组分析
Genome Announc. 2014 Mar 6;2(2):e00140-14. doi: 10.1128/genomeA.00140-14.
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Draft Genome Sequence of Multidrug-Resistant Pseudomonas aeruginosa Strain VRFPA02, Isolated from a Septicemic Patient in India.从印度一名败血症患者中分离出的多重耐药铜绿假单胞菌菌株VRFPA02的基因组序列草图
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8
Investigative modalities in infectious keratitis.感染性角膜炎的检查方法
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Microbial scleritis-experience from a developing country.微生物性巩膜炎：来自发展中国家的经验。
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从巩膜炎患者中分离出的VRFPA10的毒力基因组分析。

Virulence genome analysis of VRFPA10 recovered from patient with scleritis.

作者信息

Murugan Nandagopal, Malathi Jambulingam, Umashankar Vetrivel, Madhavan Hajib Narahari Rao

机构信息

Dept of Microbiology, L & T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 6000 06, India; Scholar, School of Chemical & Biotechnology, SASTRA University, Thanjavur, Tamil Nadu 613401, India.

Dept of Microbiology, L & T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 6000 06, India.

出版信息

Genom Data. 2017 Feb 6;12:1-3. doi: 10.1016/j.gdata.2017.02.007. eCollection 2017 Jun.

DOI:10.1016/j.gdata.2017.02.007
PMID:28217443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5302140/
Abstract

Infectious keratitis is a major cause of blindness, next to cataract and majority of cases are mainly caused by gram negative bacterium . . In this study, we investigated a . VRFPA10 genome which exhibited susceptibility to commonly used drugs but the patient had poor prognosis due to its hyper virulent nature. Genomic analysis of VRFPA10 deciphered multiple virulence factors and . Genomic Islands (PAGIs) VRFPA10 genome which correlated with hyper virulence nature of the organism. The genome sequence has been deposited in DDBJ/EMBL/GenBank under the accession numbers LFMZ01000001-LFMZ01000044.

摘要

感染性角膜炎是仅次于白内障的主要致盲原因，大多数病例主要由革兰氏阴性菌引起。在本研究中，我们调查了一株VRFPA10基因组，该基因组对常用药物敏感，但由于其高毒力特性，患者预后较差。对VRFPA10的基因组分析揭示了多种毒力因子和与该生物体高毒力特性相关的基因组岛（PAGIs）VRFPA10基因组。该基因组序列已以登录号LFMZ01000001-LFMZ01000044保存在DDBJ/EMBL/GenBank中。