甘丙肽抑制去甲肾上腺素诱导的大鼠大脑皮层中环磷酸腺苷的积累。
Galanin inhibits noradrenaline-induced accumulation of cyclic AMP in the rat cerebral cortex.
作者信息
Nishibori M, Oishi R, Itoh Y, Saeki K
机构信息
Department of Pharmacology, Okayama University Medical School, Japan.
出版信息
J Neurochem. 1988 Dec;51(6):1953-5. doi: 10.1111/j.1471-4159.1988.tb01185.x.
The effect of galanin on noradrenaline (NA)-induced accumulation of cyclic AMP was investigated in slices of rat cerebral cortex. NA (10(-4)M) increased cyclic AMP levels during a 20-min observation period. Galanin (3 X 10(-7)M) significantly inhibited this response at all time points examined, although it did not change the basal levels of cyclic AMP. Galanin (10(-8)-3 X 10(-6)M) inhibited the cyclic AMP response to NA (10(-4)M) in a dose-dependent manner, with an IC50 of approximately 5.6 X 10(-8)M and a maximum inhibition of 59%. These results suggest that galanin, devoid of any detectable effects by itself, modulates the cyclic AMP response to NA in the rat cerebral cortex.
在大鼠大脑皮层切片中研究了甘丙肽对去甲肾上腺素（NA）诱导的环磷酸腺苷（cAMP）积累的影响。在20分钟的观察期内，NA（10⁻⁴M）可提高cAMP水平。甘丙肽（3×10⁻⁷M）在所有检测的时间点均显著抑制此反应，尽管它并未改变cAMP的基础水平。甘丙肽（10⁻⁸ - 3×10⁻⁶M）以剂量依赖的方式抑制对NA（10⁻⁴M）的cAMP反应，半数抑制浓度（IC50）约为5.6×10⁻⁸M，最大抑制率为59%。这些结果表明，甘丙肽本身无任何可检测到的效应，但可调节大鼠大脑皮层对NA的cAMP反应。
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