原发性急性登革热与趋化因子受体 5 缺失（CCR5Δ32）。
Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32).
机构信息
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
出版信息
Microbes Infect. 2014 Jun;16(6):518-21. doi: 10.1016/j.micinf.2014.02.007. Epub 2014 Mar 4.
Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35-2.1).
登革热病毒是一种重要的虫媒病毒病原体，由于人类旅行和蚊虫传播到新地区，它仍在继续传播。趋化因子受体 5（CCR5）具有截短的 32 个碱基对缺失形式（CCR5Δ32），它与对 HIV 的抗性有关，但在一些黄病毒病中会增加严重程度。如果 CCR5Δ32 与登革热有关，那么携带这种突变的欧洲人可能面临更高的风险。在澳大利亚西部，与南欧相同的 CCR5Δ32 频率（0.08）的人群中，患有和未患有登革热的归国旅行者之间 CCR5Δ32 等位基因频率没有显著差异（p = 0.82，OR = 0.86，95%CI = 0.35-2.1）。
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