VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders (LIND) and University of Leuven, O&N4, Herestraat 49 Box 602, 3000 Leuven, Belgium.
VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders (LIND) and University of Leuven, O&N4, Herestraat 49 Box 602, 3000 Leuven, Belgium; Department of Molecular Neuroscience, University College London (UCL) Institute of Neurology, London, United Kingdom.
Ageing Res Rev. 2014 Sep;17:43-53. doi: 10.1016/j.arr.2014.02.006. Epub 2014 Mar 4.
Non-coding RNAs, such as microRNAs and long non-coding RNAs, represent the next major step in understanding the complexity of gene regulation and expression. In the past decade, tremendous efforts have been put mainly into identifying microRNAs that are changed in Alzheimer's disease, with the goal to provide biomarkers of the disease and to better characterize molecular pathways that are deregulated concomitantly to the formation of Tau and amyloid aggregates. This review underlines the importance of correctly defining, in a deluge of high-throughput data, which microRNAs are abnormally expressed in Alzheimer's disease patients. Despite a clear lack of consensus on the topic, miR-132 is emerging as a neuronal microRNA being gradually down-regulated during disease and showing important roles in the maintenance of brain integrity. Insight into the biological importance of other classes of non-coding RNAs also rapidly increased over the last years and therefore we discuss the possible implication of long non-coding RNAs in Alzheimer's disease.
非编码 RNA，如 microRNAs 和长非编码 RNA，代表了理解基因调控和表达复杂性的下一个主要步骤。在过去的十年中，人们主要致力于鉴定阿尔茨海默病中发生变化的 microRNAs，以期提供疾病的生物标志物，并更好地描述同时发生的分子途径，这些分子途径与 Tau 和淀粉样蛋白聚集的形成失调。这篇综述强调了在高通量数据的洪流中正确定义哪些 microRNAs 在阿尔茨海默病患者中异常表达的重要性。尽管在这个问题上缺乏明确的共识，但 miR-132 作为一种神经元 microRNA，在疾病过程中逐渐下调，并在维持大脑完整性方面发挥重要作用，正在逐渐显现出来。近年来，对其他种类的非编码 RNA 的生物学重要性的认识也迅速增加，因此我们讨论了长非编码 RNA 在阿尔茨海默病中的可能影响。
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