外泌体中非编码 RNA 在阿尔茨海默病中的新兴作用。

The emerging role of non-coding RNAs from extracellular vesicles in Alzheimer's disease.

机构信息

Department of Clinical Laboratory, Shenzhen Baoan Hospital, Southern Medical University, 518000 Shenzhen, P. R. China.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, P. R. China.

出版信息

J Integr Neurosci. 2021 Mar 30;20(1):239-245. doi: 10.31083/j.jin.2021.01.360.

DOI:10.31083/j.jin.2021.01.360

PMID:33834709

Abstract

Alzheimer's disease is an age-dependent neurodegenerative disease. Recently, different non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, have been found to contribute to Alzheimer's disease's pathogenesis. Extracellular vehicles could be enriched in ncRNAs and in their role in mediating intercellular communication. Signatures of extracellular vesicular ncRNAs have shown them to be a potential biomarker in Alzheimer's disease. This perspective discusses the potential role of extracellular vehicle ncRNAs in Alzheimer's disease, providing a theoretical basis for extracellular vesicular ncRNAs in Alzheimer's disease, from pathogenesis to diagnosis and treatment.

摘要

阿尔茨海默病是一种与年龄相关的神经退行性疾病。最近，人们发现不同的非编码 RNA（ncRNA），包括 microRNAs、长非编码 RNA 和环状 RNA，有助于阿尔茨海默病的发病机制。细胞外囊泡中可以富集 ncRNA，并在介导细胞间通讯中发挥作用。细胞外囊泡 ncRNA 的特征表明它们是阿尔茨海默病的一种潜在生物标志物。本观点讨论了细胞外囊泡 ncRNA 在阿尔茨海默病中的潜在作用，为细胞外囊泡 ncRNA 在阿尔茨海默病从发病机制到诊断和治疗提供了理论依据。