Ishibashi-Ueda H, Yutani C, Imakita M, Kanzaki T, Utsu M, Chiba Y
Division of Pathology, National Cardiovascular Center, Osaka, Japan.
Pediatr Cardiol. 1988;9(3):157-61. doi: 10.1007/BF02080557.
An autopsy case of congenital atrioventricular (AV) heart block is described. A newborn infant of a mother with systemic lupus erythematosus died 10 h after birth. Autopsy revealed hematoxylin bodies in the AV node, central fibrous body, and fibrous annulus of the heart. Also, immunoglobulin G (IgG) localization in the hematoxylin bodies was demonstrated by an immunoperoxidase technique. It is suggested that IgG or immune complexes crossed the placenta and that the immune deposition directly injured the cardiac conduction system, causing AV block.
本文描述了一例先天性房室传导阻滞的尸检病例。一名患有系统性红斑狼疮母亲的新生儿在出生后10小时死亡。尸检发现心脏的房室结、中央纤维体和纤维环中有苏木精小体。此外，通过免疫过氧化物酶技术证实了苏木精小体中有免疫球蛋白G（IgG）定位。提示IgG或免疫复合物穿过胎盘，免疫沉积直接损伤心脏传导系统，导致房室传导阻滞。
