Bondi R, Urso C, Santucci B, Santucci M, Marchesi A, Panzoni E
Istituto di Anatomia e Istologia Patologica, Università di Firenze, Italia.
Tumori. 1988 Aug 31;74(4):479-84. doi: 10.1177/030089168807400417.
A case is presented of a male patient affected by a giant cell lesion of the jaw, which had two recurrences in 8 years. Histologically, the lesion appeared to be composed of giant cells and mononuclear cells. Histoenzymatic study demonstrated acid phosphatase in both types of cells, and beta-glucuronidase in giant cells only. In some nuclei of giant cells, ultrastructural investigation showed filaments or microtubular structures of variable length, with irregular transverse periodicity, in addition to other expected findings. These characteristic features, found in giant cells of some giant cell tumors of the long bones, have never before been reported in a giant cell lesion of the jaw. The results are considered in order to assess the diagnosis, and the pathologic profiles of giant cell reparative granuloma, and of giant cell tumor are critically discussed.
本文报告一例男性患者，患有颌骨巨细胞病变，该病变在8年内复发了两次。组织学上，病变似乎由巨细胞和单核细胞组成。组织酶学研究表明，两种细胞中均存在酸性磷酸酶，而仅在巨细胞中存在β-葡萄糖醛酸酶。在巨细胞的一些细胞核中，超微结构研究显示，除了其他预期的发现外，还有长度可变、具有不规则横向周期性的细丝或微管结构。这些特征在一些长骨巨细胞瘤的巨细胞中发现，此前从未在颌骨巨细胞病变中报道过。对这些结果进行了分析，以评估诊断，并对巨细胞修复性肉芽肿和巨细胞瘤的病理特征进行了批判性讨论。
