Chuong R, Kaban L B, Kozakewich H, Perez-Atayde A
J Oral Maxillofac Surg. 1986 Sep;44(9):708-13. doi: 10.1016/0278-2391(86)90040-6.
The biologic behavior of central giant cell lesions of the jaws ranges from quiescent to aggressive with destructive expansion. To date, these variations have not been explained by the findings of routine histologic examination. This retrospective clinicopathologic study of giant cell lesions was performed to search for histologic correlates of biologic behavior. Lesions in 17 patients were classified clinically as nonaggressive (group I) or aggressive (group II). In general, group II lesions affected children at an earlier age, were larger at the time of diagnosis, and recurred more frequently. The following histologic parameters were assessed: fractional surface area occupied by giant cells (FSA), relative size index of giant cells (RSI), stromal characteristics, mitotic index, inflammatory cells, and hemosiderin content. Histologic differences between the two groups were not as clear as the differences in biologic behavior. However, aggressive lesions had a higher RSI, and recurrent giant cells lesions had a higher RSI and FSA; these parameters warrant further study. In addition, electron microscopic differences in a small number of aggressive and nonaggressive lesions were documented.
颌骨中央巨细胞病变的生物学行为从静止到侵袭性并伴有破坏性扩展不等。迄今为止，这些差异尚未通过常规组织学检查结果得到解释。进行这项巨细胞病变的回顾性临床病理研究是为了寻找生物学行为的组织学相关因素。17例患者的病变在临床上被分类为非侵袭性（I组）或侵袭性（II组）。一般来说，II组病变在儿童中发病年龄更早，诊断时体积更大，且复发更频繁。评估了以下组织学参数：巨细胞所占的表面积分数（FSA）、巨细胞的相对大小指数（RSI）、基质特征、有丝分裂指数、炎症细胞和含铁血黄素含量。两组之间的组织学差异不如生物学行为差异明显。然而，侵袭性病变的RSI较高，复发性巨细胞病变的RSI和FSA较高；这些参数值得进一步研究。此外，还记录了少数侵袭性和非侵袭性病变的电子显微镜差异。
