Morgan Rhys G, Ridsdale Jenna, Tonks Alex, Darley Richard L
School of Cellular and Molecular Medicine, University of Bristol, University Walk, Clifton, Bristol, BS8 1TD, UK.
J Cell Biochem. 2014 Aug;115(8):1351-61. doi: 10.1002/jcb.24803.
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, β-catenin. In particular, the nuclear localization of β-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling β-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of β-catenin and how they are relevant to cancer.
经典Wnt信号通路因其在人类癌症中频繁失调而成为深入研究的焦点。其中大部分研究都指向该通路的核心介质β-连环蛋白的异常表达和/或活性。特别是，β-连环蛋白的核定位以及随后TCF/LEF介导的转录的不适当激活似乎是癌症干细胞建立和维持过程中的一个重要过程。尽管如此，正常细胞和恶性细胞中控制β-连环蛋白核定位的确切机制仍知之甚少。这篇前瞻性文章汇集了先前报道的许多调节β-连环蛋白核定位的机制以及它们与癌症的相关性。
