Gould C L, Sonnenfeld G
Department of Microbiology, School of Medicine, University of Louisville, KY 40292.
J Biol Regul Homeost Agents. 1987 Jan-Mar;1(1):33-6.
Both rodents and men returning from spaceflight and the attendent microgravity or weightlessness conditions have exhibited alterations in immune responses and, in particular, interferon production. We have utilized a model for antiorthostatic (20 degrees head-down tilt). hypokinetic, hypodynamic suspension of mice that simulates some aspects of weightlessness. Female Swiss/Webster mice that are normally resistant to infection with the D variant of encephalomyocarditis virus showed a marked increase in susceptibility to infection when suspended. This correlated with a drop in interferon production. Control, orthostatically suspended mice (no head-down tilt) showed no increase in susceptibility to the virus. These data suggest that maintenance of mice in the antiorthostatic suspension model for simulating some aspects of weightlessness yielded increased susceptibility to virus infection that was coincident with inhibited interferon production.
从太空飞行返回以及处于随之而来的微重力或失重环境中的啮齿动物和人类，其免疫反应都会出现改变，尤其是干扰素的产生。我们利用了一种抗直立位（头向下倾斜20度）、低动力、低活力的小鼠悬吊模型，该模型模拟了失重的某些方面。通常对脑心肌炎病毒D变体感染具有抵抗力的雌性瑞士/韦伯斯特小鼠在悬吊时对感染的易感性显著增加。这与干扰素产生的下降相关。作为对照的直立悬吊小鼠（无头部向下倾斜）对该病毒的易感性没有增加。这些数据表明，将小鼠维持在模拟失重某些方面的抗直立位悬吊模型中会导致对病毒感染的易感性增加，同时干扰素产生受到抑制。
