Rose A, Steffen J M, Musacchia X J, Mandel A D, Sonnenfeld G
Proc Soc Exp Biol Med. 1984 Nov;177(2):253-6. doi: 10.3181/00379727-177-41939.
Mice were suspended in a model that simulates weightlessness that occurs during prolonged space flight. After 1 and 2 weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta. Interferon production was severely reduced in mice that had been suspended. When mice were allowed to recover in cages for a week following removal from suspension, they recovered their full interferon-production capacity. Mice suspended in an orthostatic (horizontal) position did not have their interferon production capabilities affected, which indicates that stress per se was not a major component in the effects of antiorthostatic suspension on interferon induction.
将小鼠置于模拟长期太空飞行中出现的失重状态的模型中。在以抗头低位（头向下倾斜）悬吊1周和2周后，用聚肌苷酸-聚胞苷酸刺激小鼠以诱导α/β干扰素。悬吊后的小鼠干扰素产生严重减少。当小鼠从悬吊状态移除后在笼中恢复1周时，它们恢复了全部的干扰素产生能力。以头高位（水平位）悬吊的小鼠其干扰素产生能力未受影响，这表明应激本身并非抗头低位悬吊对干扰素诱导作用的主要因素。
