微流控辅助自组装复杂树枝状聚乙烯药物传递纳米胶囊。
Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules.
机构信息
Laboratoire de Microsystemes (LMIS4), Institute of Microengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland; School of Materials Science and Engineering and G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA; Center of Excellence in Biomaterials, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
出版信息
Adv Mater. 2014 May 21;26(19):3118-23. doi: 10.1002/adma.201305753. Epub 2014 Mar 7.
Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.
本文提出了一种通过控制自组装制备复杂纳米胶囊的微流控平台。粒径在 50-200nm 范围内的单分散纳米胶囊由树枝状聚乙烯核和泊洛沙姆共聚物壳组成。所得纳米载体包封了大量疏水性抗癌药物如紫杉醇，同时具有低补体激活作用和高可调性的持续释放特性。
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