刺激响应性HBPS-g-PDMAEMA及其作为负载疏水分子的纳米载体的应用。

Stimuli-responsive HBPS-g-PDMAEMA and its application as nanocarrier in loading hydrophobic molecules.

作者信息

Chen Yongsheng, Wang Li, Yu Haojie, Sun Ruoli, Jing Guanghui, Tong Rongbai, Deng Zheng

机构信息

State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.

出版信息

Beilstein J Org Chem. 2016 May 10;12:939-49. doi: 10.3762/bjoc.12.92. eCollection 2016.

DOI:10.3762/bjoc.12.92

PMID:27340484

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4901927/

Abstract

The topic of stimuli-responsive nanocarriers for loading guest molecules is dynamic. It has been widely studied in applications including drug controlled release, smart sensing, catalysis, and modeling. In this paper, a graft copolymer (hyperbranched polystyrene)-g-poly[2-(dimethylamino)ethyl methacrylate] (HBPS-g-PDMAEMA) was synthesized and characterized by (1)H NMR and GPC. It was observed that the star-like HBPS-g-PDMAEMA formed aggregates in aqueous solution. The influence of polymer concentration, ionic strength and pH value on the aggregates in aqueous solution was investigated by using UV-vis spectroscopy and DLS analysis. The results showed that size of aggregates was affected by a corresponding stimulus. In addition, the loading ability of HBPS-g-PDMAEMA aggregates was investigated by using pyrene or Nile red as the model guest molecules by using UV-vis and fluorescence spectroscopy. The results showed that HBPS-g-PDMAEMA aggregates were capable to encapsulate small hydrophobic molecules. These newly prepared HBPS-g-PDMAEMA nanocarriers might be used in, e.g., medicine or catalysis.

摘要

用于负载客体分子的刺激响应性纳米载体这一主题是动态的。它已在包括药物控释、智能传感、催化和建模等应用中得到广泛研究。本文合成了一种接枝共聚物（超支化聚苯乙烯）-g-聚[2-(二甲氨基)乙基甲基丙烯酸酯]（HBPS-g-PDMAEMA），并通过¹H NMR和GPC对其进行了表征。观察到星状的HBPS-g-PDMAEMA在水溶液中形成聚集体。通过紫外可见光谱和动态光散射分析研究了聚合物浓度、离子强度和pH值对水溶液中聚集体的影响。结果表明，聚集体的尺寸受相应刺激的影响。此外，以芘或尼罗红作为模型客体分子，通过紫外可见光谱和荧光光谱研究了HBPS-g-PDMAEMA聚集体的负载能力。结果表明，HBPS-g-PDMAEMA聚集体能够包封小的疏水分子。这些新制备的HBPS-g-PDMAEMA纳米载体可用于例如医学或催化领域。