Gentile P S, Epremian B E, Seeger J, Hamm J T, Sheth S P
Division of Medical Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine 40292.
Am J Clin Oncol. 1988 Dec;11(6):666-8. doi: 10.1097/00000421-198812000-00016.
Twenty-two patients with metastatic melanoma were treated with a chemotherapy regimen consisting of two cycles of induction therapy with vinblastine, bleomycin, and cisplatin, followed by maintenance therapy with dacarbazine and dibromodulcitol. A 17% response rate was noted in this patient group, with a median survival of 40 weeks. Objective responses were limited to cutaneous, nodal, pulmonary, and one adrenal site of metastatic disease. Toxicity was acceptable and was limited to myelosuppression and nausea with emesis. Further study appears warranted to define the optimal treatment plan for metastatic melanoma.
22例转移性黑色素瘤患者接受了化疗方案治疗，该方案包括两个周期的长春碱、博来霉素和顺铂诱导治疗，随后用达卡巴嗪和二溴卫矛醇进行维持治疗。该患者组的缓解率为17%，中位生存期为40周。客观缓解仅限于皮肤、淋巴结、肺部和一个肾上腺转移部位。毒性是可接受的，仅限于骨髓抑制和恶心呕吐。进一步的研究似乎有必要确定转移性黑色素瘤的最佳治疗方案。
