Ohshiro Toshio
Ohshiro Clinic; Japan Medical Laser Laboratory; and Department of Plastic & Reconstructive Surgery, Keio University School of Medicine, Shinanomachi, Tokyo, Japan.
Laser Ther. 2012 Jul 3;21(2):97-103. doi: 10.5978/islsm.12-OR-05.
The rapidly graying population in Japan is being compounded by the rapidly-dropping birth rate. The latter is mostly due to the later ages at which women are giving birth as the marriage age has also been increasing. Giving birth at a later stage is associated with problems for both mother and child, but for older would-be mothers the greatest problem is infertility, sometimes severe. The present article will show how the application of low level laser therapy (LLLT) is a potentially effective treatment for severe infertility.
Seventy-four females (average age 39.28 yr) with severe infertility in whom assisted reproductive technology (ART) had been unsuccessful (average of 9.13 yr) participated in the first part of a study from October 1996 - April 2000. LLLT was applied (830 nm, CW, GaAlAs 60 mW diode LLLT) in Ohshiro's proximal priority technique (average 21.08 sessions) with or without other ART approaches. Based on successful outcomes, the study was then extended to March 2012, amassing a final total of 701 patients.
Pregnancy was achieved in the first part of the trial in 16 patients (21.7% of 74) of whom 11 (68%) achieved successful live delivery. In the extended trial, pregnancy was achieved in 156 (22.3% of 701) with 79 live deliveries (50.1%).
The use of 830 nm LLLT in the proximal priority technique at the parameters used in the present study, on its own or as an adjunct to other techniques, resulted in successful induction of pregnancy in just over 21% of severely infertile females, with a substantial number of these achieving live births. No adverse events were noted in any patient. LLLT is a pain-free and sideeffect free modality which could give hope to the increasing numbers of older females with infertility in Japan and potentially worldwide. Multinational studies are warranted.
日本人口迅速老龄化，同时出生率急剧下降。后者主要是由于女性生育年龄推迟，因为结婚年龄也在上升。晚育对母亲和孩子都有问题，但对于年龄较大的准母亲来说，最大的问题是不孕，有时甚至很严重。本文将展示低强度激光疗法（LLLT）的应用如何成为治疗严重不孕的一种潜在有效方法。
1996年10月至2000年4月，74名严重不孕女性（平均年龄39.28岁）参与了一项研究的第一部分，她们接受辅助生殖技术（ART）均未成功（平均不孕时间9.13年）。采用大代田近端优先技术应用LLLT（830nm，连续波，砷化镓铝60mW二极管LLLT），治疗次数平均为21.08次，同时或不联合其他ART方法。基于成功的结果，该研究随后延长至2012年3月，最终共有701名患者。
在试验的第一部分，16名患者（74名中的21.7%）成功怀孕，其中11名（68%）成功分娩活婴。在扩展试验中，156名患者（701名中的22.3%）成功怀孕，79名成功分娩活婴（50.1%）。
在本研究使用的参数下，采用近端优先技术单独或联合其他技术使用830nm LLLT，使略多于21%的严重不孕女性成功受孕，其中相当一部分成功分娩活婴。未观察到任何患者出现不良事件。LLLT是一种无痛且无副作用的治疗方式，可为日本乃至全球越来越多的老年不孕女性带来希望。有必要开展多国研究。
