Phypers Ruth, Berisha-Muharremi Venera, Hanna Reem
Laser Medicine Centre, 134 Harley Street, London W1G 7JY, UK.
Faculty of Medicine, University of Prishtina, Bulevardi i Dëshmorëve nn, 10000 Prishtina, Kosovo.
J Clin Med. 2024 Nov 24;13(23):7101. doi: 10.3390/jcm13237101.
: Female infertility due to unexpected causes exhibits a great challenge for both clinicians and women who are trying to conceive. The present clinical case series study aimed to evaluate the efficacy of multiple wavelengths of red and near-infrared (NIR) laser photobiomodulation (PBM) for increasing the potential of fertility in women and improving reproductive health in unexplained infertility issues. The objectives were to assess the following: (1) any adverse effects; (2) the possibility of producing an effective PBM protocol; (3) and healthy live birth. The inclusion criteria were to related to females who failed to conceive naturally beyond two years, multiple miscarriages, molar pregnancy, non-viable embryos from in vitro fertilisation (IVF) cycles, and failure to complete successful implantation of viable pre-implantation genetic tested (PGT-A) embryos. : Case series of three female subjects with unexplained age-related infertility issues, which included a failure to conceive naturally beyond two years, multiple miscarriages, molar pregnancy, non-viable embryos from IVF cycles, and failure to complete successful implantation of viable pre-implantation genetic tested (PGT-A) embryos. In each case, previous conditions were recorded and then compared with outcomes after the patient received a course of PBM treatments. In every case, fertility outcomes improved. Three cases resulted in a full-term pregnancy and the birth of a healthy baby. PBM treatments were given at weekly and/or at two-week intervals using IR and NIR wavelengths between 600 nm and 1000 nm in the lead up to natural conception, IVF oocyte retrieval, blastocyst/embryo implantation, and/or the production of viable embryos. : In every case, fertility outcomes improved. Improvements in reproductive health outcomes in each case give reason to suggest that PBM may help to improve unexplained age-related infertility. : Our study demonstrated that multiwavelength of red and NIR PBM with either an LED or laser, or a combination, improved female fertility and reproductive health and contributed to healthy live births in females diagnosed with unexplained age-related infertility. Extensive studies with robust data are warranted to validate our PBM dosimetry and treatment protocols. Moreover, understanding the genetic and phenotype biomarkers is important to standardise a range of PBM light dosimetry.
原因不明的女性不孕症给临床医生和试图受孕的女性都带来了巨大挑战。本临床病例系列研究旨在评估多种波长的红光和近红外（NIR）激光光生物调节（PBM）在提高女性生育潜力和改善不明原因不孕症患者生殖健康方面的疗效。目标如下：（1）任何不良反应；（2）制定有效PBM方案的可能性；（3）健康活产。纳入标准涉及自然受孕超过两年未成功、多次流产、葡萄胎妊娠、体外受精（IVF）周期中胚胎不可存活，以及植入前基因检测（PGT-A）的可存活胚胎未能成功完成着床的女性。
：三例年龄相关不明原因不孕症女性的病例系列，包括自然受孕超过两年未成功、多次流产、葡萄胎妊娠、IVF周期中胚胎不可存活，以及植入前基因检测（PGT-A）的可存活胚胎未能成功完成着床。在每个病例中，记录先前的情况，然后将患者接受一个疗程的PBM治疗后的结果与之进行比较。在每个病例中，生育结果均得到改善。三例均实现足月妊娠并诞下健康婴儿。在自然受孕、IVF取卵、囊胚/胚胎着床和/或产生可存活胚胎之前，使用600纳米至1000纳米之间的红外和近红外波长，每周和/或每两周进行一次PBM治疗。
：在每个病例中，生育结果均得到改善。每个病例生殖健康结果的改善表明PBM可能有助于改善年龄相关不明原因不孕症。
：我们的研究表明，使用发光二极管（LED）或激光或两者结合的多波长红光和近红外PBM可改善女性生育能力和生殖健康，并有助于诊断为年龄相关不明原因不孕症的女性实现健康活产。需要进行大量有充分数据的研究来验证我们的PBM剂量测定法和治疗方案。此外，了解基因和表型生物标志物对于规范一系列PBM光剂量测定法很重要。
