Kebabcı Nesrin, van Diepeningen Anne D, Ener Beyza, Ersal Tuba, Meijer Martin, Al-Hatmi Abdullah M S, Ozkocaman Vildan, Ursavaş Ahmet, Cetinoğlu Ezgi D, Akalın Halis
Faculty of Medicine, Department of Clinical Microbiology and Infectious Diseases, Uludağ University, Bursa, Turkey.
Mycoses. 2014 Apr;57(4):249-55. doi: 10.1111/myc.12142. Epub 2013 Oct 6.
Disseminated infections caused by members of the Fusarium fujikuroi species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC-member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65-year-old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission-induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.
由藤仓镰孢菌复合种（FFSC）成员引起的播散性感染在免疫功能低下的患者中经常发生。在此，我们报告首例由FFSC成员安迪镰孢菌引起的人类病例。一名65岁的急性髓性白血病男性在缓解诱导化疗期间接受泊沙康唑预防治疗，出现了发热、呼吸道症状和计算机断层扫描异常结果。在感染过程中，连续两次血液半乳甘露聚糖值呈阳性，根据形态学外观，两次血培养得到的菌株类似于镰孢菌属。基于多位点序列分型，病原体被证明是安迪镰孢菌。内部转录间隔区的测序未能区分FFSC的密切相关成员，但转录延伸因子1α亚基部分序列的额外数据做到了这一点。详细的形态学研究证实了安迪镰孢菌的鉴定，此前该菌仅被报道为影响各种粮食作物的植物病原体。
