Vesey S G, Goble N M, Stower M J, Hammonds J C, Smith P J
Department of Urology, Royal Infirmary, Bristol.
Br J Urol. 1988 Oct;62(4):347-51. doi: 10.1111/j.1464-410x.1988.tb04363.x.
Serum prostate specific antigen (PSA) was recorded in 75 patients immediately before and after transurethral resection of the prostate (TURP). Fifty-eight patients had benign prostatic hypertrophy (BPH) and 17 had prostatic carcinoma (CaP). In patients with BPH there was a statistically significant rise in PSA immediately following TURP. No such rise was seen in patients with prostatic carcinoma. A statistically significant correlation was identified between the weight of the benign hypertrophic prostate and the baseline pre-operative serum PSA. Because of the effects of TURP on serum PSA it is important to avoid PSA estimations immediately following such surgery. The failure of the malignant prostate to release PSA in significant amounts during TURP suggests that the elevated levels of PSA found in patients with prostatic carcinoma arise not from the local disease but from its metastases.
对75例患者在经尿道前列腺切除术（TURP）前后即刻记录血清前列腺特异性抗原（PSA）。58例患者为良性前列腺增生（BPH），17例为前列腺癌（CaP）。BPH患者在TURP后即刻PSA有统计学意义的升高。前列腺癌患者未见此种升高。良性增生前列腺的重量与术前基线血清PSA之间存在统计学意义的相关性。由于TURP对血清PSA的影响，在此类手术后即刻避免PSA测定很重要。恶性前列腺在TURP期间未大量释放PSA，提示前列腺癌患者中发现的PSA升高并非源于局部疾病，而是源于其转移灶。
