Bieglmayer C, Szepesi T, Neunteufel W
2nd Department of Obstetrics and Gynecology, University of Vienna, Austria.
Cancer Lett. 1988 Nov;42(3):199-206. doi: 10.1016/0304-3835(88)90305-9.
During a follow-up program, breast cancer patients were monitored with serum analyses of mucin-like carcinoma-associated antigen (MCA), CA 15.3 and carcinoembryonic antigen (CEA). Minimum as well as maximum marker values of the individual patterns were selected for further evaluation. Marker levels of risk patients differed significantly from those of patients with metastases. In several risk patients, elevated marker levels (especially of MCA) preceded clinical diagnosis of metastases for several months. In cases with already diagnosed metastases, sensitivity of MCA was comparable to CA 15.3 or CEA. The type of metastases determined marker sensitivity, concentration and the difference between maximum and minimum values.
在一项随访计划中，通过对黏蛋白样癌相关抗原（MCA）、CA 15.3和癌胚抗原（CEA）进行血清分析来监测乳腺癌患者。选择个体模式的最低以及最高标志物值进行进一步评估。高危患者的标志物水平与有转移的患者有显著差异。在一些高危患者中，标志物水平升高（尤其是MCA）比转移的临床诊断提前数月。在已经诊断出转移的病例中，MCA的敏感性与CA 15.3或CEA相当。转移类型决定了标志物的敏感性、浓度以及最高值与最低值之间的差异。
