测定乳腺癌细胞溶质中CA 15-3的意义。
The significance of determining CA 15-3 in the cytosol of breast cancer.
作者信息
Kosian K, Bieglmayer C, Neunteufel W, Dadak C
机构信息
2nd Department of Obstetrics and Gynecology, University of Vienna, Austria.
出版信息
J Cancer Res Clin Oncol. 1992;119(1):58-60. doi: 10.1007/BF01209490.
The identification of tumor markers in patients who had undergone operation for breast cancer provides important information in the follow-up in addition to evaluation by clinical and visual methods. The aim of our study was to determine the clinical prospective value of CA 15-3, mucin-like carcinoma-associated antigen and carcinoembryonic antigen in preoperative measurement of serum samples in patients with primary breast cancer, and to determine CA 15-3 and steroid receptors in the cytosol of the tumor. The results show that the most exact correlation occurred between serum CA 15-3 and the different stages of the tumor. However, there is no conclusive evidence for the prognosis and the course of the disease from preoperative findings of tumor markers in serum samples or in the cytosol of the tumor in patients with breast cancer.
对接受过乳腺癌手术的患者进行肿瘤标志物鉴定，除了通过临床和视诊方法进行评估外，还能为后续随访提供重要信息。我们研究的目的是确定CA 15-3、黏蛋白样癌相关抗原和癌胚抗原在原发性乳腺癌患者术前血清样本检测中的临床预测价值，并测定肿瘤细胞溶质中的CA 15-3和类固醇受体。结果显示，血清CA 15-3与肿瘤的不同分期之间存在最确切的相关性。然而，对于乳腺癌患者，术前血清样本或肿瘤细胞溶质中肿瘤标志物的检测结果，尚无确凿证据表明其对疾病的预后和病程有影响。
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