Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W. Green Street, Urbana, IL 61801-2906, USA.
Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W. Green Street, Urbana, IL 61801-2906, USA.
J Biomech. 2014 Apr 11;47(6):1495-8. doi: 10.1016/j.jbiomech.2014.02.022. Epub 2014 Feb 20.
We study the effects of freeze-thaw and irradiation on structure-property relations of trabecular bone. We measure the porosity, apparent density, mineral content, trabecular orientation, trabecular thickness, fractal dimension, surface area, and connectivity of trabecular bone using micro-computed tomography (micro-CT) and relate them to Young's modulus and ultimate strength measured by uniaxial compression testing. The analysis is done on six-month porcine trabecular bone from femoral heads. The effects of freeze-thaw are studied by using bones from three different groups: fresh bone and bones frozen for one and five years. We find that the porosity and apparent density have most dominant influence on the elastic modulus and strength of fresh bone. Also, five years of freezing lowers both Young's modulus and ultimate strength of trabecular bone. Additionally, the effects of radiation are investigated by comparing Young's modulus before and after micro-CT exposure. We find that the micro-CT irradiation has a negligible effect on the Young's modulus of trabecular bone. These findings provide insights on the effects of tissue preservation and imaging on properties of trabecular bone.
我们研究了冻融和辐照对松质骨结构-性能关系的影响。我们使用微计算机断层扫描（micro-CT）测量松质骨的孔隙率、表观密度、矿物质含量、骨小梁方向、骨小梁厚度、分形维数、表面积和连通性，并将其与单轴压缩试验测量的杨氏模量和极限强度相关联。分析对象是来自猪股骨头的六个月大的松质骨。通过使用来自三个不同组的骨骼来研究冻融的影响：新鲜骨骼以及冷冻了一年和五年的骨骼。我们发现，在新鲜骨骼中，孔隙率和表观密度对弹性模量和强度的影响最大。此外，五年的冷冻会降低松质骨的杨氏模量和极限强度。此外，我们通过比较 micro-CT 暴露前后的杨氏模量来研究辐照的影响。我们发现 micro-CT 辐照对松质骨的杨氏模量几乎没有影响。这些发现为组织保存和成像对松质骨性能的影响提供了深入了解。
