Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; The Norman and Helen Asher Center for the Study of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Psychiatry Res. 2014 Apr 30;222(1-2):111-3. doi: 10.1016/j.pscychresns.2014.02.001. Epub 2014 Feb 13.
Abnormal intrinsic functional connectivity, measured by resting-state functional MRI, has been reported in major depressive disorder (MDD). Our study is the first to demonstrate hypo- and hyperconnectivity between the hippocampus and cortical, subcortical regions in a genetic animal model of depression, similar to connectivity anomalies found in MDD.
静息态功能磁共振成像测量的异常固有功能连接已在重度抑郁症（MDD）中报道。我们的研究首次证明了抑郁遗传动物模型中海马和皮质、皮质下区域之间的连接异常，包括连接过度和连接不足，类似于 MDD 中发现的连接异常。
