Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
J Parkinsons Dis. 2014;4(2):237-44. doi: 10.3233/JPD-130293.
REM sleep behavior disorder (RBD) appears to have a predilection for some neurodegenerative disorders, especially synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. The frequency of RBD in PD has been reported to variably range from 20 to 72%. RBD may precede or follow onset of parkinsonism. Idiopathic RBD may foreshadow neurodegenerative diseases, and RBD in patients with PD has several associated clinical factors although their causal or temporal relationships are not known. RBD may be associated with the development of hallucinations and dementia in PD. It has been reported that the male gender, old age, a non-tremor motor subtype, a more severe parkinsonism, fall, longer disease duration, autonomic dysfunction, and higher levodopa doses are factors associated with RBD in PD. This review will address the clinical implications of RBD as a preclinical marker of neurodegenerative diseases and PD phenotypes associated with RBD.
快速眼动睡眠行为障碍（RBD）似乎偏爱某些神经退行性疾病，尤其是帕金森病（PD）、路易体痴呆和多系统萎缩等突触核蛋白病。PD 中 RBD 的频率报道从 20%到 72%不等。RBD 可能先于或后于帕金森病发作。特发性 RBD 可能预示神经退行性疾病，PD 中的 RBD 有几个相关的临床因素，尽管它们的因果或时间关系尚不清楚。RBD 可能与 PD 中的幻觉和痴呆的发展有关。有报道称，男性、老年、非震颤运动亚型、更严重的帕金森病、跌倒、更长的疾病持续时间、自主神经功能障碍和更高的左旋多巴剂量是与 PD 中 RBD 相关的因素。本综述将讨论 RBD 作为神经退行性疾病和与 RBD 相关的 PD 表型的临床前标志物的意义。
