National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, Denmark Hill, London, UK Department of Neurology, Technical University Dresden, Dresden, Germany.
National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital, Denmark Hill, London, UK.
J Parkinsons Dis. 2014;4(2):289-300. doi: 10.3233/JPD-130273.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.
深部脑刺激（DBS）丘脑底核（STN）是治疗帕金森病（PD）患者的一种成熟的疗法，尤其是那些有晚期运动并发症的患者。STN-DBS 对 PD 的非运动症状（NMS）的影响研究较少。在本文中，我们回顾了与 PD 患者的致残性运动症状共存时 STN-DBS 对 NMS 影响的相关文献。我们还提供了证据表明，大多数 NMS 的数量和严重程度在 STN-DBS 后会减少，这会对患者的生活质量产生重大影响。
