Devito R A, Brink L, Sloan C, Jolliff F
J Clin Psychiatry. 1978 Jan;39(1):26-34.
A significant number of chronic psychotic patients are readmitted to state mental hospitals each year due in large part to their inability or unwillingness to continue taking antipsychotic medication on a voluntary basis. This paper describes an ex post facto study comparing the effectiveness of fluphenazine decanoate, a long acting antipsychotic medication, with a variety of oral antipsychotics in reducing the number of readmissions of two groups of chronic psychotic patients to a state operated mental health facility. The results demonstrated that a group of 61 patients receiving fluphenazine decanoate had signigicantly fewer readmissions during the one year study period than did a comparison group on oral antipsychotics. The findings indicate that long acting antipsychotic medication, as part of an intensive outpatient treatment program, strongly militates against the tendency of chronic psychotic patients to discontinue treatment.
每年都有相当数量的慢性精神病患者被重新送进州立精神病院，这在很大程度上是由于他们无法或不愿意自愿继续服用抗精神病药物。本文描述了一项事后研究，比较了长效抗精神病药物癸酸氟奋乃静与多种口服抗精神病药物在减少两组慢性精神病患者再次入住一家州立心理健康机构的人数方面的有效性。结果表明，在为期一年的研究期间，一组61名接受癸酸氟奋乃静治疗的患者的再次入院人数明显少于服用口服抗精神病药物的对照组。研究结果表明，长效抗精神病药物作为强化门诊治疗方案的一部分，能有力地抑制慢性精神病患者中断治疗的倾向。
