I类磷脂酰肌醇-3激酶亚基在癌症中的研究进展。

Advances in subunits of PI3K class I in cancer.

作者信息

Cui Wenli, Cai Ying, Zhou Xiaoyan

机构信息

1Department of Pathology, Fudan University Shanghai Cancer Center 2Department of Oncology, Shanghai Medical College, Fudan University 3Institute of Pathology, Fudan University, Shanghai 4Department of Pathology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.

出版信息

Pathology. 2014 Apr;46(3):169-76. doi: 10.1097/PAT.0000000000000066.

DOI:10.1097/PAT.0000000000000066

PMID:24614719

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) include members of a unique and conserved family of intracellular lipid kinases that phosphorylate the 3-hydroxyl group of phosphatidylinositols and phosphoinositides. The resultant activation of many intracellular signalling pathways regulates various biological functions such as cell metabolism, survival, growth, proliferation, polarity, and apoptosis. PI3Ks are classified into three types: class I, II, and III. Of them, class I PI3K is most widely studied and plays an important role in the development and progression of tumours. In this review, we describe PI3K family members and their functions, especially the subunits of class I PI3K, their alterations in cancers, as well as PI3K inhibitors and their clinical trial status in cancer-targeted therapy.

摘要

磷脂酰肌醇3激酶（PI3Ks）是细胞内脂质激酶独特且保守家族的成员，可使磷脂酰肌醇和磷酸肌醇的3-羟基磷酸化。由此激活的许多细胞内信号通路调节各种生物学功能，如细胞代谢、存活、生长、增殖、极性和凋亡。PI3Ks分为三类：I类、II类和III类。其中，I类PI3K研究最为广泛，在肿瘤的发生和发展中起重要作用。在本综述中，我们描述了PI3K家族成员及其功能，特别是I类PI3K的亚基、它们在癌症中的改变，以及PI3K抑制剂及其在癌症靶向治疗中的临床试验状况。