van der Flier Wiesje M, Pijnenburg Yolande A L, Prins Niels, Lemstra Afina W, Bouwman Femke H, Teunissen Charlotte E, van Berckel Bart N M, Stam Cornelis J, Barkhof Frederik, Visser Pieter Jelle, van Egmond Evan, Scheltens Philip
Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands Department of Epidemiology & Biostatistics, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306.
Since its opening in 2000, patient care and research go hand in hand at the Alzheimer center of the VU University Medical Center, both organized in such a way that they mutually strengthen each other. Our mission is to give patients a voice by lifting the stigma on dementia, to find new diagnostic and treatment strategies, and, ultimately, to cure diseases that cause dementia. Our healthcare pathway is uniquely designed to accommodate all necessary investigations for the diagnostic work-up of dementia in one day (one-stop shop). A second unique feature is that research has been fully integrated in the healthcare pathway. The resulting Amsterdam Dementia Cohort now includes over 4000 patients, and for the majority of these, we have MRI, EEG, blood (serum, plasma), DNA, and CSF available. The Amsterdam Dementia Cohort forms the basis of much of our research, which focuses on four major research lines: 1) variability in manifestation, 2) early diagnosis, 3) vascular factors, and 4) interventions. By answering research questions closely related to clinical practice, the results of our research can be looped back to improve clinical work-up for our patients.
自2000年开业以来，阿姆斯特丹自由大学医学中心的阿尔茨海默病中心将患者护理与研究紧密结合，两者的组织方式相辅相成。我们的使命是消除对痴呆症的污名化，让患者能够表达心声，寻找新的诊断和治疗策略，并最终治愈导致痴呆症的疾病。我们的医疗保健流程经过独特设计，能够在一天内完成痴呆症诊断检查所需的所有必要调查（一站式服务）。另一个独特之处在于，研究已完全融入医疗保健流程。由此形成的阿姆斯特丹痴呆症队列目前包括4000多名患者，其中大多数患者的核磁共振成像（MRI）、脑电图（EEG）、血液（血清、血浆）、脱氧核糖核酸（DNA）和脑脊液样本我们都有。阿姆斯特丹痴呆症队列是我们许多研究的基础，这些研究主要集中在四个主要研究方向：1）症状表现的变异性，2）早期诊断，3）血管因素以及4）干预措施。通过回答与临床实践密切相关的研究问题，我们的研究结果可以反馈回来，以改善对患者的临床检查。
