Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
J Alzheimers Dis. 2018;62(3):1091-1111. doi: 10.3233/JAD-170850.
The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated to combine both patient care and research. Together, to date, all patients forming the Amsterdam Dementia Cohort number almost 6,000 individuals. In this cohort profile, we provide an overview of the results produced based on the Amsterdam Dementia Cohort. We describe the main results over the years in each of these research lines: 1) early diagnosis, 2) heterogeneity, and 3) vascular factors. Among the most important research efforts that have also impacted patients' lives and/or the research field, we count the development of novel, easy to use diagnostic measures such as visual rating scales for MRI and the Amsterdam IADL Questionnaire, insight in different subgroups of AD, and findings on incidence and clinical sequelae of microbleeds. Finally, we describe in the outlook how our research endeavors have improved the lives of our patients.
阿姆斯特丹记忆门诊于 2000 年在阿姆斯特丹 VU 大学医学中心成立，旨在将患者护理和研究结合起来。截至目前，所有组成阿姆斯特丹痴呆队列的患者数量已接近 6000 人。在本队列概况中，我们概述了基于阿姆斯特丹痴呆队列产生的结果。我们描述了这些研究方向中每年的主要结果：1）早期诊断，2）异质性，和 3）血管因素。在对患者生活和/或研究领域产生影响的最重要的研究工作中，我们开发了一些新颖、易于使用的诊断方法，例如 MRI 的视觉评分量表和阿姆斯特丹 IADL 问卷，对 AD 的不同亚组有了更深入的了解，以及关于微出血的发生率和临床后果的发现。最后，我们在展望部分描述了我们的研究工作如何改善了患者的生活。
