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[基于细胞的疗法治疗压力性尿失禁:哪种细胞类型,成本多少?]

[Cell-based therapy to treat stress urinary incontinence: which cell type at what cost?].

作者信息

Vaegler M, DaSilva L A, Benz K, Amend B, Mollenhauer J, Aicher W K, Stenzl A, Sievert K-D

机构信息

Klinische Forschergruppe 273, Universitätsklinik für Urologie, Tübingen, Deutschland.

出版信息

Urologe A. 2014 Mar;53(3):354-61. doi: 10.1007/s00120-013-3353-8.

DOI:10.1007/s00120-013-3353-8
PMID:24615464
Abstract

In Germany, 6-8 million woman and men suffer urinary incontinence, which represents 12.5 % of the population. It is estimated that by the middle of this century, it will increase to almost 30 %. The primary reason will be primarily related to the aging population but also to patient awareness and seeking a solution. In addition to the cost which is covered by the health insurance, the patient will spend more than half a billion euro/year out-of-pocket, not to mention the social stigma associated with urinary incontinence. The current common treatment options are symptomatic but do not restore functionality. One option might be tissue engineering or stem cell therapy. This article describes the likelihood that this therapy will change the approach in treating stress urinary incontinence. Boundaries and legal aspects are highlighted as well as approximated cost. These treatment costs might be currently higher than the standard treatment options, but the investment to reduce these costs are paid indirectly by society.

摘要

在德国,有600万至800万女性和男性患有尿失禁,占总人口的12.5%。据估计,到本世纪中叶,这一比例将增至近30%。主要原因首先与人口老龄化有关,但也与患者意识及寻求解决方案有关。除了医疗保险所涵盖的费用外,患者每年还将自掏腰包花费超过5亿欧元,更不用说与尿失禁相关的社会耻辱感了。目前常见的治疗方法只是缓解症状,无法恢复功能。一种选择可能是组织工程或干细胞疗法。本文描述了这种疗法改变压力性尿失禁治疗方法的可能性。文中强调了其界限和法律方面以及大致成本。目前这些治疗成本可能高于标准治疗方法,但降低这些成本的投资是由社会间接支付的。

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[Cell-based therapy to treat stress urinary incontinence: which cell type at what cost?].[基于细胞的疗法治疗压力性尿失禁:哪种细胞类型,成本多少?]
Urologe A. 2014 Mar;53(3):354-61. doi: 10.1007/s00120-013-3353-8.
2
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本文引用的文献

1
The advance transobturator male sling for post-prostatectomy incontinence: subjective and objective outcomes with 3 years follow up.用于前列腺切除术后尿失禁的新型经闭孔男性吊带:3年随访的主观和客观结果
Neurourol Urodyn. 2015 Mar;34(3):251-4. doi: 10.1002/nau.22539. Epub 2013 Dec 7.
2
Stem cell therapy in bladder dysfunction: where are we? And where do we have to go?干细胞治疗膀胱功能障碍:我们在哪里?我们要去哪里?
Biomed Res Int. 2013;2013:930713. doi: 10.1155/2013/930713. Epub 2013 Sep 16.
3
Outcomes of artificial urinary sphincter implantation in the irradiated patient.
人工尿失禁括约肌植入术在放疗患者中的应用效果。
BJU Int. 2014 Apr;113(4):636-41. doi: 10.1111/bju.12518. Epub 2014 Feb 14.
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Continence and complications rates after male slings as primary surgery for post-prostatectomy incontinence: a systematic review.
Arch Ital Urol Androl. 2013 Jun 24;85(2):92-5. doi: 10.4081/aiua.2013.2.92.
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Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2.胎盘间充质基质细胞成骨分化潜能低与转录因子 Runx2 和 Twist2 表达水平低有关。
Stem Cells Dev. 2013 Nov 1;22(21):2859-72. doi: 10.1089/scd.2012.0693. Epub 2013 Jul 20.
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Use of stem cells for ischemic cardiomyopathy--reply.干细胞用于缺血性心肌病——回复
JAMA. 2013 Apr 10;309(14):1458-9. doi: 10.1001/jama.2013.2893.
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Use of stem cells for ischemic cardiomyopathy.干细胞在缺血性心肌病中的应用。
JAMA. 2013 Apr 10;309(14):1458. doi: 10.1001/jama.2013.2890.
8
Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?间质干细胞分泌组:中枢神经系统再生的新模式?
Cell Mol Life Sci. 2013 Oct;70(20):3871-82. doi: 10.1007/s00018-013-1290-8. Epub 2013 Mar 1.
9
Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity.从单个肌纤维中分拣单个卫星细胞揭示了细胞表面标志物和生肌能力的异质性。
Integr Biol (Camb). 2013 Apr;5(4):692-702. doi: 10.1039/c3ib20290a. Epub 2013 Feb 13.
10
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.经心内膜注射异体与自体骨髓间充质干细胞治疗缺血性心肌病的比较:POSEIDON 随机试验。
JAMA. 2012 Dec 12;308(22):2369-79. doi: 10.1001/jama.2012.25321.