Wu Hongyu, Zhu Ren
Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China,
Tumour Biol. 2014 Jun;35(6):6055-63. doi: 10.1007/s13277-014-1802-7. Epub 2014 Mar 12.
Several genome-wide association studies on lung cancer (LC) have reported similar findings of a new susceptibility locus, 5p15. After that, a number of studies reported that the rs2736100, rs401681, rs402710, and rs31489 polymorphisms at chromosome 5p15 have been implicated in LC risk. However, the studies have yielded contradictory results. To derive a more precise estimation of the relationship, we performed this meta-analysis. Databases including MEDLINE, PubMed, EMBASE, ISI Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of association. The random effect model was applied, addressing heterogeneity and publication bias. A total of 31 articles involving 72,401 cases and 141,258 controls were included. Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis. In the subgroup analysis by ethnicity, sample size, histology, sex, and smoking behavior, significantly increased risks were also detected for these polymorphisms. Our findings demonstrated that these common variations at 5p15 are a risk factor associated with increased LC susceptibility. However, these associations vary between different ethnicity.
多项关于肺癌（LC）的全基因组关联研究报告了一个新的易感基因座5p15的类似发现。此后，一些研究报告称，5号染色体5p15上的rs2736100、rs401681、rs402710和rs31489多态性与肺癌风险有关。然而，这些研究得出了相互矛盾的结果。为了更精确地估计这种关系，我们进行了这项荟萃分析。检索了包括MEDLINE、PubMed、EMBASE、ISI科学网和中国知网（CNKI）在内的数据库以查找相关研究。使用比值比（OR）和95%置信区间（CI）来评估关联强度。应用随机效应模型来处理异质性和发表偏倚。总共纳入了31篇文章，涉及72401例病例和141258例对照。总体而言，当所有研究汇总到荟萃分析中时，rs2736100、rs401681、rs402710和rs31489多态性与肺癌风险显著升高相关。在按种族、样本量、组织学、性别和吸烟行为进行的亚组分析中，也检测到这些多态性的风险显著增加。我们的研究结果表明，5p15处的这些常见变异是与肺癌易感性增加相关的危险因素。然而，这些关联在不同种族之间有所不同。
