Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Nat Genet. 2012 Jul 15;44(8):900-3. doi: 10.1038/ng.2353.
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P(combined) = 2.8 × 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P(combined) = 6.9 × 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P(combined) = 7.4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
肺腺癌是最常见的肺癌组织学类型，其发病率在全球范围内呈上升趋势。为了确定影响肺腺癌风险的遗传因素，我们在日本人群中进行了全基因组关联研究和两项验证研究，共纳入了 6029 例肺腺癌患者（病例）和 13535 例对照。我们确认了两个先前报道的风险位点，5p15.33（rs2853677，P(combined) = 2.8 × 10(-40)，比值比（OR）= 1.41）和 3q28（rs10937405，P(combined) = 6.9 × 10(-17)，OR = 1.25），并确定了两个新的易感位点，17q24.3（rs7216064，P(combined) = 7.4 × 10(-11)，OR = 1.20）和 6p21.3（rs3817963，P(combined) = 2.7 × 10(-10)，OR = 1.18）。这些数据进一步证实了遗传易感性在肺腺癌发生发展中的作用。
