Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China.
Adv Mater. 2014 May;26(17):2694-8, 2016. doi: 10.1002/adma.201304744. Epub 2014 Feb 24.
The effect of the anchoring group of surface ligands on the magnetic properties, especially relaxometric properties, of PEGylated Fe₃ O₄ nanoparticles is investigated. Systematic experimental results together with in-depth theoretical analysis reveal that the ligand binding affinity can largely vary the saturation magnetization, whereas conjugated anchoring groups can remarkably enhance the transverse relaxivity, which highlights a novel approach for achieving high-performance MRI contrast agents.
研究了表面配体的锚固基团对 PEG 化 Fe3O4 纳米粒子的磁性，特别是弛豫性能的影响。系统的实验结果和深入的理论分析表明，配体结合亲和力可以很大程度上改变饱和磁化强度，而共轭锚固基团可以显著提高横向弛豫率，这为实现高性能 MRI 造影剂提供了一种新方法。
