Zhang Dongmei, Zhang Jing, Bian Xianglin, Zhang Pei, Wu Weihua, Zuo Xudong
School of Mathematics and Physics, Jiangsu University of Technology, Changzhou 213100, China.
The Jiangsu Key Laboratory of Clean Energy Storage and Conversion, Jiangsu University of Technology, Changzhou 213100, China.
Nanomaterials (Basel). 2024 Dec 28;15(1):33. doi: 10.3390/nano15010033.
This review highlights recent progress in utilizing iron oxide nanoparticles (IONPs) as a safer alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). It consolidates findings from multiple studies, discussing current T contrast agents (CAs), the synthesis techniques for IONPs, the theoretical principles for designing IONP-based MRI CAs, and the key factors that impact their T contrast efficacy, such as nanoparticle size, morphology, surface modifications, valence states, and oxygen vacancies. Furthermore, we summarize current strategies to achieve IONP-based responsive CAs, including self-assembly/disassembly and distance adjustment. This review also evaluates the biocompatibility, organ accumulation, and clearance pathways of IONPs for clinical applications. Finally, the challenges associated with the clinical translation of IONP-based T CAs are included.
本综述重点介绍了利用氧化铁纳米颗粒（IONPs）作为钆基造影剂（GBCAs）的更安全替代品用于磁共振成像（MRI）的最新进展。它整合了多项研究的结果，讨论了当前的T造影剂（CAs）、IONPs的合成技术、基于IONP的MRI CAs的设计理论原则，以及影响其T造影效果的关键因素，如纳米颗粒大小、形态、表面修饰、价态和氧空位。此外，我们总结了实现基于IONP的响应性CAs的当前策略，包括自组装/拆卸和距离调整。本综述还评估了IONPs在临床应用中的生物相容性、器官蓄积和清除途径。最后，还包括了基于IONP的T CAs临床转化所面临的挑战。
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