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Are we systematically under-dosing patients with fluorouracil?

作者信息

Patel Kalpesh, Iacobuzio-Donahue Christine A, Gormley Paul E, Kern Scott E, Cunningham Steven C

机构信息

Johns Hopkins Medical Institutions, Baltimore, MD.

St Agnes Cancer Institute, Baltimore, MD.

出版信息

J Clin Oncol. 2015 Mar 1;33(7):e36-7. doi: 10.1200/JCO.2013.49.5044. Epub 2014 Mar 10.

DOI:10.1200/JCO.2013.49.5044
PMID:24616306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4334781/
Abstract
摘要

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1
A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing.一种胸苷酸合成酶三元复合物特异性抗体FTS，可用于监测氟嘧啶给药的功能。
Oncotarget. 2012 Jul;3(7):678-85. doi: 10.18632/oncotarget.554.
2
Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.初步观察表明，在结直肠癌患者中优化输注 5-氟尿嘧啶（5-FU）剂量期间，血浆 5-FU 水平的变化模式不同。
Cancer Biol Ther. 2011 Oct 1;12(7):557-68. doi: 10.4161/cbt.12.7.18059.
3
Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine.雷帕霉素靶蛋白抑制剂依维莫司联合卡培他滨的 Ib 期研究。
J Clin Oncol. 2010 Oct 20;28(30):4554-61. doi: 10.1200/JCO.2009.27.5867. Epub 2010 Sep 20.
4
Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: results of a multicenter randomized trial of patients with metastatic colorectal cancer.基于药代动力学随访的氟尿嘧啶个体化剂量调整与传统剂量比较：转移性结直肠癌患者多中心随机试验结果
J Clin Oncol. 2008 May 1;26(13):2099-105. doi: 10.1200/JCO.2007.13.3934.
5
A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.一种用于监测氟嘧啶治疗的临床检测方法：胸苷酸合成酶三元复合物的检测与稳定性
Cancer Biol Ther. 2006 Aug;5(8):923-7. doi: 10.4161/cbt.5.8.2976. Epub 2006 Aug 2.
6
Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106.用单克隆抗体TS 106对胸苷酸合酶-FdUMP-5,10-亚甲基四氢叶酸三元复合物进行免疫定量分析。
Anticancer Drugs. 1993 Aug;4(4):431-5. doi: 10.1097/00001813-199308000-00002.
7
Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.定位人细胞和组织细胞质中人类胸苷酸合成酶的单克隆抗体的制备与特性分析
Cancer Res. 1991 Dec 15;51(24):6668-76.