Dingledine R, Boland L M, Chamberlin N L, Kawasaki K, Kleckner N W, Traynelis S F, Verdoorn T A
Department of Pharmacology and Neurobiology Curriculum, University of North Carolina School of Medicine, Chapel Hill.
Crit Rev Neurobiol. 1988;4(1):1-96.
The inhibitory and excitatory amino acid neurotransmitter receptors in the mammalian central nervous system mediate functionally opposite synaptic responses yet appear to share certain structural features. Recent conceptual advances in this field have relied heavily on information obtained by single channel analyses, by the expression of receptors in oocytes, and by autoradiographic studies of receptor distribution among brain receptors. This article reviews the pharmacology, cellular physiology, and regional distribution of these receptors and discusses their role in several well-characterized neurological disease states. Also reviewed are the recent advances made in purifying (in some instances cloning) the receptors and uptake sites involved in synaptic transmission in the brain. Throughout, the emphasis is on synthesis and concept rather than on methodological detail.
哺乳动物中枢神经系统中的抑制性和兴奋性氨基酸神经递质受体介导功能相反的突触反应，但似乎具有某些共同的结构特征。该领域最近的概念进展在很大程度上依赖于通过单通道分析、在卵母细胞中表达受体以及对脑受体中受体分布的放射自显影研究获得的信息。本文综述了这些受体的药理学、细胞生理学和区域分布，并讨论了它们在几种特征明确的神经疾病状态中的作用。还综述了在纯化（在某些情况下克隆）参与脑内突触传递的受体和摄取位点方面取得的最新进展。通篇重点在于综合与概念，而非方法细节。
