一个谷氨酸受体基因家族：形成具有不同通道特性的异源多聚体受体的证据。
A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties.
作者信息
Nakanishi N, Shneider N A, Axel R
机构信息
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
出版信息
Neuron. 1990 Nov;5(5):569-81. doi: 10.1016/0896-6273(90)90212-x.
Abstract
We have isolated two cDNA clones (GluR-K2 and GluR-K3) that share considerable sequence identity with the previously described glutamate receptor subunit, GluR-K1. The three glutamate receptor subunits show significant sequence conservation with the glutamine binding component of the glutamine permease of E. coli. Each of these clones encodes a channel responsive to both kainate and AMPA. The coexpression of GluR-K2 with either GluR-K3 or GluR-K1 results in the formation of channels whose current-voltage relationships differ from those of the individual subunits alone and more closely approximate the properties of kainate receptors in neurons. These observations indicate that the kainate/quisqualate receptors are encoded by a family of genes and are likely to be composed of hetero-oligomers of at least two distinct subunits.
摘要
我们分离出了两个cDNA克隆（GluR-K2和GluR-K3），它们与先前描述的谷氨酸受体亚基GluR-K1具有相当高的序列同一性。这三个谷氨酸受体亚基与大肠杆菌谷氨酰胺通透酶的谷氨酰胺结合成分显示出显著的序列保守性。这些克隆中的每一个都编码一个对海人酸和AMPA都有反应的通道。GluR-K2与GluR-K3或GluR-K1共表达会导致通道的形成，其电流-电压关系不同于单独的单个亚基，并且更接近神经元中海人酸受体的特性。这些观察结果表明，海人酸/quisqualate受体由一个基因家族编码，并且可能由至少两个不同亚基的异源寡聚体组成。
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